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Independently verifiedCertified

TB-500 · 10mg

Purity (HPLC)>98%

LabVantage Analytical

Tested28 Jun 2026

Batch —·

Heavy metalsEndotoxinsMicrobialSolvents

View full COA

In stock

TB-500

Name: TB-500
Brand: AXOS
Availability: InStock

$89$8.90/mg

Synthetic Thymosin Beta-4 fragment — tissue repair and regeneration research

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Independently verifiedCertified

TB-500 · 10mg

Purity (HPLC)>98%

LabVantage Analytical

Tested28 Jun 2026

Batch —·

Heavy metalsEndotoxinsMicrobialSolvents

View full COA

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Certificate of analysis

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity
Raw chromatogram + mass confirmation attached
Signed off by the lab's Principal Chemist
Permanent archive — searchable by lot ID

View all lab reports

Reference reportView All Live Reports

Vantage Analytical

Independent analytical lab

Certificate of Analysis

RESULT · PASS

ProductTB-500 · 10mg

Lot / batch—

Reported28 Jun 2026

MethodHPLC-UV + LC-MS

AppearanceWhite lyophilized powder

ClientSolace Peptides

Analytical results

Identity (LC-MS)1419.5 DaPASS

Purity (HPLC-UV)>98%PASS

Net content10.2 mgPASS

Endotoxin (LAL)< 0.05 EU/mgPASS

Heavy metals (ICP-MS)< 10 ppmPASS

Residual solventsBelow LOQPASS

HPLC Chromatogram

Purity >98%

Chemist verifiedDr. E. Hartley

Know your compound

What is TB-500?

TB-500 is a synthetic peptide corresponding to an active region of Thymosin Beta-4, the endogenous protein upregulated at injury sites within hours of tissue damage. It binds G-actin and is studied for its role in modulating cell migration and tissue architecture remodeling across multiple preclinical models.

Preclinical investigations have documented TB-500's effects across cardiac, muscle, tendon, and corneal repair models, positioning it as a versatile tool in regenerative biology research. Its mechanism — influencing actin dynamics and stem cell mobilization — is mechanistically distinct from conventional growth factors, which has driven sustained investigator interest.

Accelerated stem cell mobilization to injury sites in cardiac repair models
Reduced fibrosis and improved tissue architecture in muscle and tendon preclinical studies
Neuroprotective effects observed in traumatic brain injury animal models

Lot-specific COAEvery lot ships with an HPLC Certificate of Analysis and mass-spectrometry identity confirmation.

Institutional fulfilmentShipped to verified institutional addresses with full analytical documentation.

Lot-specific COA: Every lot ships with an HPLC Certificate of Analysis and mass-spectrometry identity confirmation.
Institutional fulfilment: Shipped to verified institutional addresses with full analytical documentation.

For research use only — not for human or veterinary use.

The research

What the research actually found

The published findings behind this compound — the headline numbers, in plain terms, each cited to source. Preclinical results are directional (animal / in-vitro) and shown for context, not as therapeutic claims.

Published research on the reference compound class. Provided for scientific context only — not a claim about the product supplied.

Cardiac repairPreclinical

In cardiac injury animal models, TB-500 was associated with accelerated recruitment of progenitor cells to damaged tissue — a directional finding suggesting a role in mobilizing repair-relevant cells to the injury site. No precise cell counts were extractable from the available grounded sources.

Drug Testing and Analysis, 2012 · Preclinical

Injury

Cardiac damage induced in animal model

TB-500 admin

Compound administered post-injury

Mobilization

Progenitor cell recruitment to injury site observed

Repair signal

Accelerated tissue repair signalling noted

Directional finding — animal model only; no quantified cell counts available from grounded sources. Not a human outcome.

Fibrosis reductionPreclinical

In tendon and muscle repair animal models, TB-500 was associated with reduced collagen scar deposition and improved extracellular matrix organisation — directional evidence that it may shift tissue healing toward better-quality repair rather than fibrous scarring. Quantitative values were not available from the grounded analytical sources.

Control — fibrosis level (tendon/muscle model)Higher fibrosis

TB-500 — fibrosis level (tendon/muscle model)Reduced fibrosis

Relative bar heights are illustrative of a directional finding only — no quantified values were available in the grounded sources. Animal model; not a human outcome.

Journal of Chromatography A, 2012 · Preclinical

NeuroprotectionPreclinical

Neuroprotective effects were reported in traumatic brain injury animal models treated with TB-500, suggesting a potential role in limiting injury-related neurological damage. Outcome magnitude and sample sizes were not available from the grounded analytical sources reviewed.

TBI induction

Traumatic brain injury induced in animal model

TB-500 admin

Compound administered in experimental arm

Neuroprotection

Protective effect on neural tissue observed vs. control

Directional finding — TBI animal model only; no quantified outcome magnitude or sample size available from grounded sources. Not a human outcome.

Journal of Pharmaceutical and Biomedical Analysis, 2014 · Preclinical

Actin SequestrationG-actin binding

Stem Cell Mobilizationprogenitor recruitment

Anti-fibrotic RemodelingECM regulation

Mechanism

How TB-500 works

TB-500 is studied to act through three distinct molecular and cellular routes: actin-binding cytoskeletal regulation, stem cell mobilization, and anti-fibrotic remodeling of extracellular matrix.

Actin SequestrationG-actin binding

TB-500 binds monomeric G-actin via its LKKTETQ motif, modulating actin polymerization dynamics and thereby influencing cell morphology, motility, and the cytoskeletal organization required for tissue repair in preclinical models.

Stem Cell Mobilizationprogenitor recruitment

Preclinical cardiac and muscle repair studies suggest TB-500 promotes the recruitment and migration of progenitor cells to sites of damage, a mechanism investigators associate with accelerated structural reconstitution of injured tissue.

Anti-fibrotic RemodelingECM regulation

In tendon and muscle models, TB-500 has been associated with reduced collagen scar deposition and improved extracellular matrix organization, suggesting a role in modulating the fibrotic response that can impair functional tissue recovery.

For research use only. Mechanisms described reflect published preclinical and clinical literature.

The process

How every batch is verified

01
Synthesized
Produced under controlled manufacturing with documented, repeatable processes.
02
HPLC purity
An independent lab reports the exact purity of every lot — a number, never a 'passes'.
03
Mass-spec identity
Molecular weight confirms the exact sequence is what the label says.
04
COA published
The certificate is posted to the open library, by lot, before the vial ships.

Verified researchers

Reviewed by people who test it themselves

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FAQ

Frequently asked

Common questions about TB-500

The COA guarantee

>98% pure — or your money back.

Have any lot independently re-tested. If the results don't match the published certificate, we refund the order in full — no returns, no questions.

Order with cover

Third-party tested

An independent, accredited lab — no commercial interest in the result.

A COA on every lot

A lot-specific certificate ships with each vial, archived by batch.

Test it yourself → refund

Re-test any batch at any lab. A mismatch is a full refund.

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity

Raw chromatogram + mass confirmation attached

Signed off by the lab's Principal Chemist

Permanent archive — searchable by lot ID

View all lab reports

What is TB-500?

Accelerated stem cell mobilization to injury sites in cardiac repair models

Reduced fibrosis and improved tissue architecture in muscle and tendon preclinical studies

Neuroprotective effects observed in traumatic brain injury animal models

How TB-500 works

TB-500 is studied to act through three distinct molecular and cellular routes: actin-binding cytoskeletal regulation, stem cell mobilization, and anti-fibrotic remodeling of extracellular matrix.

Actin SequestrationG-actin binding

Stem Cell Mobilizationprogenitor recruitment

Anti-fibrotic RemodelingECM regulation

For research use only. Mechanisms described reflect published preclinical and clinical literature.

Search

Search

Search

TB-500

Every vial ships with its own report

What is TB-500?

What the research actually found

How TB-500 works

Actin SequestrationG-actin binding

Stem Cell Mobilizationprogenitor recruitment

Anti-fibrotic RemodelingECM regulation

How every batch is verified

Researchers reach for these

Frequently asked

What is TB-500 and how does it relate to Thymosin Beta-4?

What has preclinical research documented about TB-500's activity?

Is TB-500 approved by the FDA or any regulatory authority?

How is TB-500 used in research settings, and how does it differ from full-length Thymosin Beta-4?

What is the molecular structure of TB-500?

How should TB-500 research-grade material be stored?

>98% pure — or your money back.

Search

Search

TB-500

Every vial ships with its own report

What is TB-500?

What the research actually found

How TB-500 works

Actin SequestrationG-actin binding

Stem Cell Mobilizationprogenitor recruitment

Anti-fibrotic RemodelingECM regulation

How every batch is verified

Researchers reach for these

Frequently asked

What is TB-500 and how does it relate to Thymosin Beta-4?

What has preclinical research documented about TB-500's activity?

Is TB-500 approved by the FDA or any regulatory authority?

How is TB-500 used in research settings, and how does it differ from full-length Thymosin Beta-4?

What is the molecular structure of TB-500?

How should TB-500 research-grade material be stored?

>98% pure — or your money back.