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5 Amino 1MQ · 50mg

Purity (HPLC)≥98%

LabVantage Analytical

Tested28 Jun 2026

Batch —·

Heavy metalsEndotoxinsMicrobialSolvents

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In stock

5 Amino 1MQ

Name: 5 Amino 1MQ
Brand: AXOS
Availability: InStock

$89$1.78/mg

Small-molecule NNMT inhibitor — diet-induced obesity research

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Independently verifiedCertified

5 Amino 1MQ · 50mg

Purity (HPLC)≥98%

LabVantage Analytical

Tested28 Jun 2026

Batch —·

Heavy metalsEndotoxinsMicrobialSolvents

View full COA

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Certificate of analysis

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity
Raw chromatogram + mass confirmation attached
Signed off by the lab's Principal Chemist
Permanent archive — searchable by lot ID

View all lab reports

Reference reportView All Live Reports

Vantage Analytical

Independent analytical lab

Certificate of Analysis

RESULT · PASS

Product5 Amino 1MQ · 50mg

Lot / batch—

Reported28 Jun 2026

MethodHPLC-UV + LC-MS

AppearanceWhite lyophilized powder

ClientSolace Peptides

Analytical results

Identity (LC-MS)1419.5 DaPASS

Purity (HPLC-UV)≥98%PASS

Net content10.2 mgPASS

Endotoxin (LAL)< 0.05 EU/mgPASS

Heavy metals (ICP-MS)< 10 ppmPASS

Residual solventsBelow LOQPASS

HPLC Chromatogram

Purity ≥98%

Chemist verifiedDr. E. Hartley

Know your compound

What is 5 Amino 1MQ?

5-Amino-1MQ is a selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme upregulated in obese adipose tissue that regulates NAD+ and S-adenosylmethionine (SAM) cellular pools. Its molecular target sits upstream of the metabolic dysfunction associated with adipose NNMT overexpression.

In a diet-induced obesity murine model, NNMT inhibition with 5-Amino-1MQ produced significant fat mass reduction without altering food intake — a dissociation that distinguishes this mechanism from appetite-mediated interventions. Concurrent preservation of lean mass in the same model has made it a subject of active preclinical metabolic investigation.

Fat mass reduced in diet-induced obese mice — with no change in food intake
Lean/muscle mass preserved alongside fat loss in animal models
NNMT inhibition restored depleted NAD+ and SAM pools in adipose tissue

Lot-specific COAEvery lot ships with an HPLC Certificate of Analysis and mass-spectrometry identity confirmation.

Institutional fulfilmentShipped to verified institutional addresses with full analytical documentation.

Lot-specific COA: Every lot ships with an HPLC Certificate of Analysis and mass-spectrometry identity confirmation.
Institutional fulfilment: Shipped to verified institutional addresses with full analytical documentation.

For research use only — not for human or veterinary use.

The research

What the research actually found

The published findings behind this compound — the headline numbers, in plain terms, each cited to source. Preclinical results are directional (animal / in-vitro) and shown for context, not as therapeutic claims.

Published research on the reference compound class. Provided for scientific context only — not a claim about the product supplied.

Fat loss without dietingPreclinical

In diet-induced obese mice, 5-Amino-1MQ reduced fat mass significantly compared to vehicle controls — and food intake stayed the same throughout, suggesting the effect is independent of appetite suppression. Finding from Neelakantan et al., 2019.

vs. vehicle control · food intake unchanged

Journal of Medicinal Chemistry, 2019

Vehicle control — fat massbaseline (obese mice)

5-Amino-1MQ — fat masssignificantly reduced

Diet-induced obesity murine model · Neelakantan et al., 2019. Exact % not extracted from source; bar heights reflect directional significance only.

Muscle preservedPreclinical

While fat mass fell, lean mass remained intact in 5-Amino-1MQ-treated obese mice compared to controls — a dissociation rarely seen with caloric-restriction-driven weight loss. Directional finding, Neelakantan et al., 2019.

vs. vehicle control · fat mass reduced concurrently

Vehicle control — lean massbaseline lean mass

5-Amino-1MQ — lean masspreserved

5-Amino-1MQ — fat masssignificantly reduced

Diet-induced obesity murine model · Neelakantan et al., 2019. Lean-mass bars reflect preservation (directional); fat-mass bar reflects significant reduction. No exact % extracted from source.

Journal of Medicinal Chemistry, 2019

Metabolic cofactors restoredPreclinical

NNMT inhibition with 5-Amino-1MQ partially restored depleted NAD⁺ and SAM cofactor pools in adipose tissue of obese mice — two metabolic signals linked to energy expenditure and fat-cell function. Directional finding, Neelakantan et al., 2019.

vs. obese vehicle controls · adipose tissue assay

NAD⁺ — adipose tissueSAM — adipose tissue

Diet-induced obesity murine model · adipose tissue assay · Neelakantan et al., 2019. Slope heights are directional — exact fold-change not extracted from source material.

Journal of Medicinal Chemistry, 2019

NNMT inhibitioncompetitive inhibitor

NAD+/SAM restorationone-carbon metabolism

Adipocyte energy fluxmetabolic reprogramming

Mechanism

How 5 Amino 1MQ works

5-Amino-1MQ is studied to act through three mechanistically distinct routes: enzymatic inhibition of NNMT, downstream restoration of methyl-donor and NAD+ cofactor pools, and consequent modulation of adipocyte energy metabolism.

NNMT inhibitioncompetitive inhibitor

5-Amino-1MQ competitively occupies the substrate-binding site of nicotinamide N-methyltransferase, blocking methylation of nicotinamide and attenuating NNMT activity in adipose tissue in preclinical models.

NAD+/SAM restorationone-carbon metabolism

By suppressing NNMT-mediated nicotinamide methylation, the compound is studied to reduce consumption of S-adenosylmethionine (SAM) and support recovery of NAD+ salvage flux — cofactor pools that are depleted in obese adipose tissue.

Adipocyte energy fluxmetabolic reprogramming

Restored cofactor availability is proposed to shift adipocyte energy handling away from lipid storage, an effect studied in diet-induced obesity models where fat mass declined without caloric restriction.

For research use only. Mechanisms described reflect published preclinical and clinical literature.

The process

How every batch is verified

01
Synthesized
Produced under controlled manufacturing with documented, repeatable processes.
02
HPLC purity
An independent lab reports the exact purity of every lot — a number, never a 'passes'.
03
Mass-spec identity
Molecular weight confirms the exact sequence is what the label says.
04
COA published
The certificate is posted to the open library, by lot, before the vial ships.

Verified researchers

Reviewed by people who test it themselves

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FAQ

Frequently asked

Common questions about 5 Amino 1MQ

The COA guarantee

≥98% pure — or your money back.

Have any lot independently re-tested. If the results don't match the published certificate, we refund the order in full — no returns, no questions.

Order with cover

Third-party tested

An independent, accredited lab — no commercial interest in the result.

A COA on every lot

A lot-specific certificate ships with each vial, archived by batch.

Test it yourself → refund

Re-test any batch at any lab. A mismatch is a full refund.

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity

Raw chromatogram + mass confirmation attached

Signed off by the lab's Principal Chemist

Permanent archive — searchable by lot ID

View all lab reports

What is 5 Amino 1MQ?

Fat mass reduced in diet-induced obese mice — with no change in food intake

Lean/muscle mass preserved alongside fat loss in animal models

NNMT inhibition restored depleted NAD+ and SAM pools in adipose tissue

How 5 Amino 1MQ works

NNMT inhibitioncompetitive inhibitor

NAD+/SAM restorationone-carbon metabolism

Adipocyte energy fluxmetabolic reprogramming

For research use only. Mechanisms described reflect published preclinical and clinical literature.

Search

Search

Search

5 Amino 1MQ

Every vial ships with its own report

What is 5 Amino 1MQ?

What the research actually found

How 5 Amino 1MQ works

NNMT inhibitioncompetitive inhibitor

NAD+/SAM restorationone-carbon metabolism

Adipocyte energy fluxmetabolic reprogramming

How every batch is verified

Researchers reach for these

Frequently asked

What is 5-Amino-1MQ and what is its biochemical basis?

What has preclinical research demonstrated about 5-Amino-1MQ?

Is 5-Amino-1MQ approved by the FDA or any regulatory agency?

How is 5-Amino-1MQ used in a research context, and how does it differ from GLP-1-based metabolic research tools?

What is the molecular structure of 5-Amino-1MQ?

How should 5-Amino-1MQ be stored and handled in the laboratory?

≥98% pure — or your money back.

Search

Search

5 Amino 1MQ

Every vial ships with its own report

What is 5 Amino 1MQ?

What the research actually found

How 5 Amino 1MQ works

NNMT inhibitioncompetitive inhibitor

NAD+/SAM restorationone-carbon metabolism

Adipocyte energy fluxmetabolic reprogramming

How every batch is verified

Researchers reach for these

Frequently asked

What is 5-Amino-1MQ and what is its biochemical basis?

What has preclinical research demonstrated about 5-Amino-1MQ?

Is 5-Amino-1MQ approved by the FDA or any regulatory agency?

How is 5-Amino-1MQ used in a research context, and how does it differ from GLP-1-based metabolic research tools?

What is the molecular structure of 5-Amino-1MQ?

How should 5-Amino-1MQ be stored and handled in the laboratory?

≥98% pure — or your money back.