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Semax · 10mg

Purity (HPLC)≥98%

LabVantage Analytical

Tested28 Jun 2026

Batch —·

Heavy metalsEndotoxinsMicrobialSolvents

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In stock

Semax

Name: Semax
Brand: AXOS
Availability: InStock

$59$5.90/mg

Synthetic ACTH(4-10) analog — BDNF and neuroprotection research

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Independently verifiedCertified

Semax · 10mg

Purity (HPLC)≥98%

LabVantage Analytical

Tested28 Jun 2026

Batch —·

Heavy metalsEndotoxinsMicrobialSolvents

View full COA

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Certificate of analysis

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity
Raw chromatogram + mass confirmation attached
Signed off by the lab's Principal Chemist
Permanent archive — searchable by lot ID

View all lab reports

Reference reportView All Live Reports

Vantage Analytical

Independent analytical lab

Certificate of Analysis

RESULT · PASS

ProductSemax · 10mg

Lot / batch—

Reported28 Jun 2026

MethodHPLC-UV + LC-MS

AppearanceWhite lyophilized powder

ClientSolace Peptides

Analytical results

Identity (LC-MS)1419.5 DaPASS

Purity (HPLC-UV)≥98%PASS

Net content10.2 mgPASS

Endotoxin (LAL)< 0.05 EU/mgPASS

Heavy metals (ICP-MS)< 10 ppmPASS

Residual solventsBelow LOQPASS

HPLC Chromatogram

Purity ≥98%

Chemist verifiedDr. E. Hartley

Know your compound

What is Semax?

Semax is a synthetic heptapeptide analog of ACTH(4-10), originally developed and approved in Russia for stroke recovery investigation. It is studied for its effects on neurotrophin gene expression and neuroprotection in models of cerebral ischemia.

In rat focal ischemia models, Semax activated transcription of BDNF and its receptor genes — a finding that positions it as a tool for investigating neuroplasticity-linked signaling pathways. Genome-wide transcriptional analysis further identified broad effects on immune and vascular gene networks in ischemic brain tissue.

Upregulated BDNF and NGF receptor gene transcription in rat cerebral ischemia models
Modulated immune and vascular gene networks in ischemic rat brain (genome-wide analysis)
Activated dopaminergic and serotonergic systems in rodent brain studies

Lot-specific COAEvery lot ships with an HPLC Certificate of Analysis and mass-spectrometry identity confirmation.

Institutional fulfilmentShipped to verified institutional addresses with full analytical documentation.

Lot-specific COA: Every lot ships with an HPLC Certificate of Analysis and mass-spectrometry identity confirmation.
Institutional fulfilment: Shipped to verified institutional addresses with full analytical documentation.

For research use only — not for human or veterinary use.

The research

What the research actually found

The published findings behind this compound — the headline numbers, in plain terms, each cited to source. Preclinical results are directional (animal / in-vitro) and shown for context, not as therapeutic claims.

Published research on the reference compound class. Provided for scientific context only — not a claim about the product supplied.

Stroke recoveryClinical

In a Russian clinical study of ischemic stroke patients, Semax-treated individuals showed improved neurological outcome measures compared to a control group. Independent replication is lacking, and effect sizes were not extractable from the available source.

Zhurnal nevrologii i psikhiatrii 2018 · Clinical

Baseline

Ischemic stroke patients enrolled

Treatment

Semax administered across stroke stages

Follow-up

Neurological outcomes assessed

Result

Improved outcomes vs. control group

Gusev et al., 2018 — single Russian clinical study; quantitative effect sizes not available in public abstract. RUO only.

Neurotrophic signalingPreclinical

In a rat focal cerebral ischemia model, Semax activated transcription of BDNF, NGF, and their receptor genes (including TrkB) compared to ischemia controls — pointing to a neuroplasticity-linked signaling pathway as a focus of its activity.

BDNF transcript — Semax↑ elevated

BDNF transcript — ischemia controlbaseline

TrkB receptor transcript — Semax↑ elevated

Relative transcript levels — rat focal ischemia model (Dmitrieva et al., 2010). Precise fold-changes not available; bars show direction only. RUO only.

Cellular and Molecular Neurobiology 2010 · Preclinical

Brain gene networksPreclinical

Genome-wide transcriptional analysis in a rat focal ischemia model found that Semax broadly altered expression across immune-response and vascular-remodeling gene networks in ischemic brain tissue — suggesting multi-pathway involvement beyond any single target.

Immune-response genes↑/↓ modulatedVascular-remodeling genes↑/↓ modulatedOther differentially expressed↑/↓ modulated

Proportional share of differentially expressed gene categories — rat focal ischemia model (Medvedeva et al., 2014). Exact gene counts not available in public abstract; segments are illustrative of reported category breakdown. RUO only.

BMC Genomics 2014 · Preclinical

Dopamine & serotoninPreclinical

In rodent brain microdialysis studies, Semax raised extracellular dopamine and serotonin concentrations across multiple forebrain regions compared to controls — indicating activation of both monoaminergic systems in the animal model.

Dopamine — Semax↑ elevated

Dopamine — controlbaseline

Serotonin — Semax↑ elevated

Extracellular monoamine levels — rodent forebrain regions (Eremin et al., 2005). Quantitative values not extractable from available source; bars show direction only. RUO only.

Neurochemical Research 2005 · Preclinical

Neurotrophin signalingBDNF / TrkB axis

Monoamine modulationdopamine / serotonin

Immune-vascular gene regulationtranscriptional networks

Mechanism

How Semax works

Semax is studied to act through three distinct molecular and cellular routes in models of cerebral ischemia and neurological function.

Neurotrophin signalingBDNF / TrkB axis

Semax is studied for its ability to upregulate transcription of BDNF and NGF receptor genes in ischemic neural tissue, potentially amplifying endogenous neuroplasticity-associated signaling cascades.

Monoamine modulationdopamine / serotonin

In rodent brain preparations, Semax has been associated with elevated extracellular dopamine and serotonin in forebrain regions, suggesting interaction with monoaminergic neurotransmission independent of its neurotrophin effects.

Immune-vascular gene regulationtranscriptional networks

Genome-wide profiling in a rat focal ischemia model identified Semax-associated changes in expression of genes governing inflammatory response and vascular remodeling, pointing to a transcriptional modulatory role in the ischemic microenvironment.

For research use only. Mechanisms described reflect published preclinical and clinical literature.

The process

How every batch is verified

01
Synthesized
Produced under controlled manufacturing with documented, repeatable processes.
02
HPLC purity
An independent lab reports the exact purity of every lot — a number, never a 'passes'.
03
Mass-spec identity
Molecular weight confirms the exact sequence is what the label says.
04
COA published
The certificate is posted to the open library, by lot, before the vial ships.

Verified researchers

Reviewed by people who test it themselves

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FAQ

Frequently asked

Common questions about Semax

The COA guarantee

≥98% pure — or your money back.

Have any lot independently re-tested. If the results don't match the published certificate, we refund the order in full — no returns, no questions.

Order with cover

Third-party tested

An independent, accredited lab — no commercial interest in the result.

A COA on every lot

A lot-specific certificate ships with each vial, archived by batch.

Test it yourself → refund

Re-test any batch at any lab. A mismatch is a full refund.

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity

Raw chromatogram + mass confirmation attached

Signed off by the lab's Principal Chemist

Permanent archive — searchable by lot ID

View all lab reports

What is Semax?

Upregulated BDNF and NGF receptor gene transcription in rat cerebral ischemia models

Modulated immune and vascular gene networks in ischemic rat brain (genome-wide analysis)

Activated dopaminergic and serotonergic systems in rodent brain studies

How Semax works

Semax is studied to act through three distinct molecular and cellular routes in models of cerebral ischemia and neurological function.

Neurotrophin signalingBDNF / TrkB axis

Semax is studied for its ability to upregulate transcription of BDNF and NGF receptor genes in ischemic neural tissue, potentially amplifying endogenous neuroplasticity-associated signaling cascades.

Monoamine modulationdopamine / serotonin

Immune-vascular gene regulationtranscriptional networks

For research use only. Mechanisms described reflect published preclinical and clinical literature.

Search

Search

Search

Semax

Every vial ships with its own report

What is Semax?

What the research actually found

How Semax works

Neurotrophin signalingBDNF / TrkB axis

Monoamine modulationdopamine / serotonin

Immune-vascular gene regulationtranscriptional networks

How every batch is verified

Researchers reach for these

Frequently asked

What is Semax and where does it originate?

What has preclinical research shown about Semax and BDNF?

Is Semax FDA approved?

How does Semax differ from native ACTH(4-10) in a research context?

What is the molecular structure of Semax?

What are the recommended storage conditions for Semax (10 mg)?

≥98% pure — or your money back.

Search

Search

Semax

Every vial ships with its own report

What is Semax?

What the research actually found

How Semax works

Neurotrophin signalingBDNF / TrkB axis

Monoamine modulationdopamine / serotonin

Immune-vascular gene regulationtranscriptional networks

How every batch is verified

Researchers reach for these

Frequently asked

What is Semax and where does it originate?

What has preclinical research shown about Semax and BDNF?

Is Semax FDA approved?

How does Semax differ from native ACTH(4-10) in a research context?

What is the molecular structure of Semax?

What are the recommended storage conditions for Semax (10 mg)?

≥98% pure — or your money back.