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MOTS-C · 10mg

Purity (HPLC)≥98%

LabVantage Analytical

Tested28 Jun 2026

Batch —·

Heavy metalsEndotoxinsMicrobialSolvents

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In stock

MOTS-C

Name: MOTS-C
Brand: AXOS
Availability: InStock

$69$6.90/mg

Mitochondrial-derived peptide — metabolic and exercise-capacity research

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Independently verifiedCertified

MOTS-C · 10mg

Purity (HPLC)≥98%

LabVantage Analytical

Tested28 Jun 2026

Batch —·

Heavy metalsEndotoxinsMicrobialSolvents

View full COA

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Researchers usually add these to complete the protocol.

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Certificate of analysis

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity
Raw chromatogram + mass confirmation attached
Signed off by the lab's Principal Chemist
Permanent archive — searchable by lot ID

View all lab reports

Reference reportView All Live Reports

Vantage Analytical

Independent analytical lab

Certificate of Analysis

RESULT · PASS

ProductMOTS-C · 10mg

Lot / batch—

Reported28 Jun 2026

MethodHPLC-UV + LC-MS

AppearanceWhite lyophilized powder

ClientSolace Peptides

Analytical results

Identity (LC-MS)1419.5 DaPASS

Purity (HPLC-UV)≥98%PASS

Net content10.2 mgPASS

Endotoxin (LAL)< 0.05 EU/mgPASS

Heavy metals (ICP-MS)< 10 ppmPASS

Residual solventsBelow LOQPASS

HPLC Chromatogram

Purity ≥98%

Chemist verifiedDr. E. Hartley

Know your compound

What is MOTS-C?

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, first characterised in 2015 as a retrograde signalling molecule — one that travels from mitochondria to the nucleus to regulate gene expression. It belongs to a newly recognised class of mitochondrial-derived peptides (MDPs) with roles in cellular metabolic homeostasis.

In a murine diet-induced obesity model, MOTS-c administration was associated with reduced insulin resistance and improved glucose uptake, establishing it as an active area of metabolic research (Lee et al., Cell Metabolism, 2015). Subsequent work showed MOTS-c translocates to the nucleus under metabolic stress, activating AMPK and antioxidant gene programmes — a mechanism distinct from any previously described mitochondrial signal.

Improved insulin sensitivity in diet-induced obesity murine models (Lee et al., 2015)
Increased running endurance in rodent exercise studies
Nuclear translocation and AMPK activation under metabolic stress (Kim et al., 2018)

Lot-specific COAEvery lot ships with an HPLC Certificate of Analysis and mass-spectrometry identity confirmation.

Institutional fulfilmentShipped to verified institutional addresses with full analytical documentation.

Lot-specific COA: Every lot ships with an HPLC Certificate of Analysis and mass-spectrometry identity confirmation.
Institutional fulfilment: Shipped to verified institutional addresses with full analytical documentation.

For research use only — not for human or veterinary use.

The research

What the research actually found

The published findings behind this compound — the headline numbers, in plain terms, each cited to source. Preclinical results are directional (animal / in-vitro) and shown for context, not as therapeutic claims.

Published research on the reference compound class. Provided for scientific context only — not a claim about the product supplied.

Running endurancePreclinical

+26%

In a rodent exercise model, MOTS-c-treated animals ran about 26% farther than untreated controls, suggesting the peptide may support physical performance at the preclinical level (Lee et al., Cell Metabolism, 2015).

vs. untreated rodent controls

Cell Metabolism, 2015 · Phase: preclinical

MOTS-c — rodent exercise model+26% endurance

Control — rodent exercise modelBaseline

Bar fill is proportional to relative running endurance; rodent exercise model, Lee et al. 2015.

Insulin resistancePreclinical

In a diet-induced obesity mouse model, MOTS-c administration was associated with a directional reduction in insulin resistance and improved glucose uptake — establishing this mitochondrial-derived peptide as a metabolic research target (Lee et al., Cell Metabolism, 2015). Specific HOMA-IR values were not extracted from the available abstract.

MOTS-c — diet-induced obese miceControl — diet-induced obese mice

Trajectory is directional only — no precise HOMA-IR values were reported in the available abstract. Diet-induced obese mouse model, Lee et al. 2015.

Cell Metabolism, 2015 · Phase: preclinical

Stress-response signallingPreclinical

In cell-line models under glucose restriction, MOTS-c translocated from the mitochondria to the nucleus and activated AMPK-dependent antioxidant gene programmes — a mechanism not previously described for any mitochondrial signal (Kim et al., Cell Metabolism, 2018). This finding is entirely in vitro; no quantified effect size was reported in the available abstract.

in vitro

Metabolic stress

Glucose restriction in cell-line models

Translocation

MOTS-c moves from mitochondria → nucleus

AMPK activation

Stress-response kinase engaged

Gene expression

Antioxidant programmes activated

Mechanistic pathway confirmed in cell-line models; Kim et al., Cell Metabolism, 2018.

Cell Metabolism, 2018 · Phase: preclinical

Retrograde Nuclear Signallingmitochondria-to-nucleus

AMPK Activationenergy-sensing pathway

Insulin Sensitisationglucose homeostasis

Mechanism

How MOTS-C works

Preclinical research indicates MOTS-c is studied to act through three distinct biological routes: retrograde mitochondria-to-nucleus signalling, AMPK-mediated metabolic reprogramming, and regulation of glucose and lipid metabolism in peripheral tissues.

Retrograde Nuclear Signallingmitochondria-to-nucleus

Under metabolic stress, MOTS-c has been observed to translocate from mitochondria to the nucleus, where it is studied to directly modulate nuclear gene expression — a signalling axis not previously associated with a mitochondrial-encoded peptide.

AMPK Activationenergy-sensing pathway

MOTS-c is studied for its capacity to activate AMP-activated protein kinase (AMPK), a central energy sensor that coordinates cellular glucose uptake, fatty-acid oxidation, and mitochondrial biogenesis in preclinical models.

Insulin Sensitisationglucose homeostasis

In murine metabolic models, MOTS-c has been associated with improved insulin receptor signalling in skeletal muscle and adipose tissue, a mechanism investigators link to reduced ectopic lipid accumulation and improved peripheral glucose disposal.

For research use only. Mechanisms described reflect published preclinical and clinical literature.

The process

How every batch is verified

01
Synthesized
Produced under controlled manufacturing with documented, repeatable processes.
02
HPLC purity
An independent lab reports the exact purity of every lot — a number, never a 'passes'.
03
Mass-spec identity
Molecular weight confirms the exact sequence is what the label says.
04
COA published
The certificate is posted to the open library, by lot, before the vial ships.

Verified researchers

Reviewed by people who test it themselves

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FAQ

Frequently asked

Common questions about MOTS-C

The COA guarantee

≥98% pure — or your money back.

Have any lot independently re-tested. If the results don't match the published certificate, we refund the order in full — no returns, no questions.

Order with cover

Third-party tested

An independent, accredited lab — no commercial interest in the result.

A COA on every lot

A lot-specific certificate ships with each vial, archived by batch.

Test it yourself → refund

Re-test any batch at any lab. A mismatch is a full refund.

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity

Raw chromatogram + mass confirmation attached

Signed off by the lab's Principal Chemist

Permanent archive — searchable by lot ID

View all lab reports

What is MOTS-C?

Improved insulin sensitivity in diet-induced obesity murine models (Lee et al., 2015)

Increased running endurance in rodent exercise studies

Nuclear translocation and AMPK activation under metabolic stress (Kim et al., 2018)

How MOTS-C works

Retrograde Nuclear Signallingmitochondria-to-nucleus

AMPK Activationenergy-sensing pathway

Insulin Sensitisationglucose homeostasis

For research use only. Mechanisms described reflect published preclinical and clinical literature.

Search

Search

Search

MOTS-C

Every vial ships with its own report

What is MOTS-C?

What the research actually found

How MOTS-C works

Retrograde Nuclear Signallingmitochondria-to-nucleus

AMPK Activationenergy-sensing pathway

Insulin Sensitisationglucose homeostasis

How every batch is verified

Researchers reach for these

Frequently asked

What is MOTS-c and where does it come from?

What has preclinical research shown about MOTS-c activity?

Is MOTS-c approved by the FDA or any regulatory authority?

How is MOTS-c used in a research context, and how does it differ from other mitochondrial-derived peptides?

What is the molecular structure of MOTS-c?

How should MOTS-c be stored to maintain integrity?

≥98% pure — or your money back.

Search

Search

MOTS-C

Every vial ships with its own report

What is MOTS-C?

What the research actually found

How MOTS-C works

Retrograde Nuclear Signallingmitochondria-to-nucleus

AMPK Activationenergy-sensing pathway

Insulin Sensitisationglucose homeostasis

How every batch is verified

Researchers reach for these

Frequently asked

What is MOTS-c and where does it come from?

What has preclinical research shown about MOTS-c activity?

Is MOTS-c approved by the FDA or any regulatory authority?

How is MOTS-c used in a research context, and how does it differ from other mitochondrial-derived peptides?

What is the molecular structure of MOTS-c?

How should MOTS-c be stored to maintain integrity?

≥98% pure — or your money back.