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Melanotan 2 · 10mg

Purity (HPLC)≥98%

LabVantage Analytical

Tested28 Jun 2026

Batch —·

Heavy metalsEndotoxinsMicrobialSolvents

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Melanotan 2

Name: Melanotan 2
Brand: AXOS
Availability: InStock

$49$4.90/mg

Synthetic alpha-MSH analog — melanocortin receptor research

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Independently verifiedCertified

Melanotan 2 · 10mg

Purity (HPLC)≥98%

LabVantage Analytical

Tested28 Jun 2026

Batch —·

Heavy metalsEndotoxinsMicrobialSolvents

View full COA

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Researchers usually add these to complete the protocol.

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Certificate of analysis

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity
Raw chromatogram + mass confirmation attached
Signed off by the lab's Principal Chemist
Permanent archive — searchable by lot ID

View all lab reports

Reference reportView All Live Reports

Vantage Analytical

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Certificate of Analysis

RESULT · PASS

ProductMelanotan 2 · 10mg

Lot / batch—

Reported28 Jun 2026

MethodHPLC-UV + LC-MS

AppearanceWhite lyophilized powder

ClientSolace Peptides

Analytical results

Identity (LC-MS)1419.5 DaPASS

Purity (HPLC-UV)≥98%PASS

Net content10.2 mgPASS

Endotoxin (LAL)< 0.05 EU/mgPASS

Heavy metals (ICP-MS)< 10 ppmPASS

Residual solventsBelow LOQPASS

HPLC Chromatogram

Purity ≥98%

Chemist verifiedDr. E. Hartley

Know your compound

What is Melanotan 2?

Melanotan 2 is a cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH), engineered for enhanced receptor binding stability relative to the native ligand. It acts as a non-selective agonist across melanocortin receptor subtypes MC1R, MC3R, MC4R, and MC5R.

Central melanocortin signaling — particularly through MC4R and its upstream regulator POMC — is an active area of hypothalamic appetite and energy-balance research. Disruption of POMC processing or MC4R-pathway components in murine models produces obesity phenotypes, establishing Melanotan 2 as a pharmacological probe for dissecting these circuits.

MC4R agonism linked to anorexigenic signaling in hypothalamic paraventricular nucleus neurons
POMC-pathway disruption in murine models causes hyperphagia and increased adiposity
MC1R activation studied as a driver of melanogenesis in pigmentation research

Lot-specific COAEvery lot ships with an HPLC Certificate of Analysis and mass-spectrometry identity confirmation.

Institutional fulfilmentShipped to verified institutional addresses with full analytical documentation.

Lot-specific COA: Every lot ships with an HPLC Certificate of Analysis and mass-spectrometry identity confirmation.
Institutional fulfilment: Shipped to verified institutional addresses with full analytical documentation.

For research use only — not for human or veterinary use.

The research

What the research actually found

The published findings behind this compound — the headline numbers, in plain terms, each cited to source. Preclinical results are directional (animal / in-vitro) and shown for context, not as therapeutic claims.

Published research on the reference compound class. Provided for scientific context only — not a claim about the product supplied.

Appetite signalingPreclinical

In a mouse model with reduced Sim1 gene dosage, melanocortin-driven appetite suppression was impaired and paraventricular nucleus neurons showed reduced activation compared to wild-type controls — pinpointing MC4R-pathway integrity as essential for anorexigenic signaling.

Molecular Endocrinology, 2006 · PMID 16728530

MC4R activated

Melanotan 2 engages MC4R in hypothalamus

PVN neurons fire

Paraventricular nucleus signals satiety

Sim1 haploinsufficiency

Reduced Sim1 dose blunts PVN activation

Anorexia impaired

Melanocortin-mediated food suppression fails — Kublaoui et al., 2006

Directional murine finding (Sim1+/− model). No quantified effect size reported in abstract.

POMC & obesityPreclinical

Mice lacking the Gpr45 receptor developed obesity alongside measurably lower hypothalamic POMC expression than wild-type animals, suggesting Gpr45 is a regulator of the POMC-melanocortin axis — the same pathway probed by MC4R agonists like Melanotan 2.

Wild-type — POMC expressionNormal

Gpr45-KO — POMC expressionReduced

Relative bar heights are directional only — no quantified fold-change was reported in the abstract. Gpr45-knockout mouse model; Cui et al., 2016.

Journal of Clinical Investigation, 2016 · PMID 27500489

POMC processingPreclinical

Mice deficient in CAPS2 — a protein involved in peptide secretion — accumulated POMC in the pituitary and displayed altered food-intake behavior, indicating that downstream processing of POMC precursor is required for normal appetite regulation via the melanocortin pathway.

Wild-type — pituitary POMCBaseline

CAPS2-KO — pituitary POMCAccumulated

Bar heights are directional only — no quantified fold-change reported. CAPS2-knockout mouse model; Fujima et al., 2020.

Neuroscience Letters, 2020 · PMID 32891671

MC1Rmelanogenesis pathway

MC4Rhypothalamic circuit

MC3R / MC5Rperipheral receptors

Mechanism

How Melanotan 2 works

Melanotan 2 is studied primarily through three melanocortin receptor-mediated pathways that are active in distinct tissue compartments.

MC1Rmelanogenesis pathway

MC1R agonism in melanocytes stimulates the cAMP cascade driving tyrosinase-dependent melanin synthesis, making it the primary pathway studied in pigmentation research.

MC4Rhypothalamic circuit

MC4R activation in paraventricular nucleus neurons is associated with anorexigenic signaling and energy-balance regulation in preclinical models, and is a central mechanistic target in obesity-circuit research.

MC3R / MC5Rperipheral receptors

Lower-affinity engagement of MC3R and MC5R has been investigated in the context of peripheral energy partitioning and exocrine gland function, though these pathways are less characterised than MC1R and MC4R in the published literature.

For research use only. Mechanisms described reflect published preclinical and clinical literature.

The process

How every batch is verified

01
Synthesized
Produced under controlled manufacturing with documented, repeatable processes.
02
HPLC purity
An independent lab reports the exact purity of every lot — a number, never a 'passes'.
03
Mass-spec identity
Molecular weight confirms the exact sequence is what the label says.
04
COA published
The certificate is posted to the open library, by lot, before the vial ships.

Verified researchers

Reviewed by people who test it themselves

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FAQ

Frequently asked

Common questions about Melanotan 2

The COA guarantee

≥98% pure — or your money back.

Have any lot independently re-tested. If the results don't match the published certificate, we refund the order in full — no returns, no questions.

Order with cover

Third-party tested

An independent, accredited lab — no commercial interest in the result.

A COA on every lot

A lot-specific certificate ships with each vial, archived by batch.

Test it yourself → refund

Re-test any batch at any lab. A mismatch is a full refund.

Every vial ships with its own report

We don't publish a brand-wide spec sheet and call it a “COA.” The certificate you receive references the actual lot number stamped on your vial — with the raw chromatograms attached.

Lot-specific HPLC purity + LC-MS identity

Raw chromatogram + mass confirmation attached

Signed off by the lab's Principal Chemist

Permanent archive — searchable by lot ID

View all lab reports

What is Melanotan 2?

MC4R agonism linked to anorexigenic signaling in hypothalamic paraventricular nucleus neurons

POMC-pathway disruption in murine models causes hyperphagia and increased adiposity

MC1R activation studied as a driver of melanogenesis in pigmentation research

How Melanotan 2 works

Melanotan 2 is studied primarily through three melanocortin receptor-mediated pathways that are active in distinct tissue compartments.